Citing a relative scarcity of research on the efficacy of CBT for GAD as compared to pharmacotherapy, Kristin Mitte conducted a meta-analysis of 65 controlled studies using a random-effects model to produce results that could be generalized beyond the selected studies. A “trim-and-fill analysis” was also conducted to correct for publication bias, several additional sensitivity analyses were performed to ensure the robustness of the selected studies, and methodological differences were controlled for. Studies utilizing new techniques in CBT such as mindfulness practices and interpersonal interventions were excluded due to insufficient research.

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